发明名称 |
USE OF CELL-SPECIFIC CONJUGATES FOR TREATMENT OF INFLAMMATORY DISEASES OF THE GASTROINTESTINAL TRACT |
摘要 |
The present invention is directed to methods for the prevention and treatment of inflammatory diseases, disorders, and conditions of gastrointestinal tract by administering to a patient in need of such treatment, conjugate compounds of Formula (VII) having low oral- bioavailability, or pharmaceutically acceptable salts, prodrugs, or solvate thereof wherein M represents a macrolide subunit possessing the property of accumulation in inflammatory cells, T represents an anti-inflammatory subunit that can be a steroid or nonsteroid (nonsteroidal moiety) derived from a non-steroid drug with anti- inflammatory, analgesic and/or antipyretic activity (NSAID) and L represents a linker covalently linking M and T. The present disclosure is also directed to pharmaceutical compositions containing conjugate compounds of Formula VII having low oral-bioavailability. |
申请公布号 |
WO2007093840(A2) |
申请公布日期 |
2007.08.23 |
申请号 |
WO2006IB01488 |
申请日期 |
2006.02.15 |
申请人 |
GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O.;MERCEP, MLADEN;MESIC, MILAN;TOMASKOVIC, LINDA;MARKOVIC, STRIBOR |
发明人 |
MERCEP, MLADEN;MESIC, MILAN;TOMASKOVIC, LINDA;MARKOVIC, STRIBOR |
分类号 |
A61K47/48;A61P1/00;A61P29/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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