发明名称 |
Compositions and methods for affecting virulence determinants in bacteria |
摘要 |
A novel sarR gene and sarR gene product which down regulates the expression of sarA and the resulting virulence determinants in Staphylococcus aureus is provided. Methods for modulating the expression of sarA and virulence determinants are also provided. A preferred embodiment of the present invention provides structural information relating to the gene product and enables the identification and formulation of lead compounds and reducements for treating and preventing infections by S. aureus and related bacteria.
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申请公布号 |
US7258995(B2) |
申请公布日期 |
2007.08.21 |
申请号 |
US20020043539 |
申请日期 |
2002.01.11 |
申请人 |
TRUSTEES OF DARTMOUTH COLLEGE |
发明人 |
CHEUNG AMBROSE L.;MANNA ADHAR;ZHANG GONGYI |
分类号 |
C12Q1/18;A61K38/00;C07K14/31 |
主分类号 |
C12Q1/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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