| 摘要 |
PROBLEM TO BE SOLVED: To obtain an intermediate useful for producing (-)-threo-3-(3,4-dihydroxyphenyl)-L-serine and to provide a method for producing the same. SOLUTION: The optically active (-)-threo-3-(3,4-dihydroxyphenyl)-L-serine (DOPS)-protected compound is produced by aminohydroxylating a cinnamic acid derivative such as methyl 3,4-dimethoxycinnamate, methyl 3,4-diethoxycinnamate, ethyl 3,4-diethoxycinnamate, methyl (2E)-3-(3,4-bisphenylmethoxyphenyl)propanoate, methyl (2E)-3-[(3,4-methylenedioxy)phenyl]propanoate, ethyl (2E)-3-[(3,4-methylenedioxy)phenyl]propanoate, ethyl (2E)-3-[(3,4-isopropylidenedioxy)phenyl]propanoate, etc., in the presence of an asymmetric catalyst. COPYRIGHT: (C)2007,JPO&INPIT
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