Human neuronal nicotinic acetylcholine receptor compositions and methods employing same

摘要

DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for producing alpha and beta subunits and recombinant (i.e., isolated or substantially pure) alpha subunits (specifically alpha₆) and beta subunits (specifically beta₃) are provided. In addition, combinations of a plurality of subunits (i.e., one or more of alpha₁, alpha₂, alpha₃, alpha₄, alpha₅, alpha₆ and/or alpha₇ subunits in combination with one or more of beta₃ subunits are provided.