发明名称 TAT-039 AND METHODS OF ASSESSING AND TREATING CANCER
摘要 <p>Surprisingly, the present inventors have discovered that expression of TAT-039 protein in human patients is associated with cancer, and that the overexpressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-039 is associated with abnormal development and growth, and may be useful as a target for the identification of anti-cancer compounds, including antibodies for use in immunotherapy. Accordingly, the present invention provides methods for the identification of compounds that inhibit TAT-039 expression or activity, comprising: contacting a candidate compound with a TAT-039 and detecting the presence or absence of binding between said compound and said TAT-039, or detecting a change in TAT-039 expression or activity. Methods are also included for the identification of compounds that modulate TAT-039 expression or activity, comprising: administering a compound to a cell or cell population, and detecting a change in TAT-039 expression or activity. The methods of the invention are useful for the identification of anti-cancer compounds.</p>
申请公布号 WO2007089659(A2) 申请公布日期 2007.08.09
申请号 WO2007US02294 申请日期 2007.01.26
申请人 CAPRION PHARMACEUTICAL, INC.;CHELSKY, DANIEL;KEARNEY, PAUL, E.;PARAMITHIOTIS, EUSTACHE;HAMAIDI, LYES;KONDEJEWSKI, LESLIE, H.;LANOIX, JOEL;HUGO, PATRICE 发明人 CHELSKY, DANIEL;KEARNEY, PAUL, E.;PARAMITHIOTIS, EUSTACHE;HAMAIDI, LYES;KONDEJEWSKI, LESLIE, H.;LANOIX, JOEL;HUGO, PATRICE
分类号 A01K67/027;A61K39/00;C07H21/04;C07K14/82;C07K16/30;C12P21/06;C12Q1/68;G01N33/574 主分类号 A01K67/027
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