Piperidine derivatives

摘要

For example, a piperidine derivative represented by following formula (I) (wherein, -C(-O)-Z- represents -C(-O)-CH₂-, -C(-O)-C(CH₃)₂-, -C(-O)-NH-, -C(-O)-O-, -C(-O)-S-, -C(-O)-CH₂CH₂-, -C(-O)-CH-CH-, -C(-O)-CH₂O-, -C(-O)-CH₂S-, -C(-O)-CH₂CH₂CH₂- or -C(-O)-NR⁸CH₂-; R¹ represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like; R² represents a hydrogen atom or hydroxy; R³ represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like; R⁵ represents a hydrogen atom, hydroxy, or the like; R⁶ represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkyl, or the like, etc.; R⁷ represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, or the like; n and k each independently represents an integer of 0 to 2; and ---- represents a single bond, or a double bond together with R⁴, where in case ---- is a single bond, R⁴ represents a hydrogen atom, hydroxy, or the like) or a pharmaceutically acceptable salt thereof and the like having an antagonistic activity for a glutamic acid receptor (NR2B/NMDA receptor) of an N-methyl-D-aspartic acid (NMDA) type containing an NR2B subunit are provided.