Cyanine dye compounds linked to metal chelator for bi-modal diagnostic imaging

摘要

The present invention relates to compounds of formula I,
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ Ch-L-D€ƒ€ƒ€ƒ€ƒ€ƒ(I),
wherein D is a cyanine dye, L is a covalent bond or a linker and Ch is a metal chelating moiety or a pharmaceutically acceptable salt thereof, which can be used for the preparation of a contrast agent for the at least bi-modal diagnostic imaging of a biological system as well as a contrast agent prepared from these compounds, their use in multi-modal diagnostic imaging and imaging methods.