摘要 |
Antibodies directed to the antigen Ang-2 and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen Ang-2. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementary determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobin molecules and monoclonal antibodies. |
申请人 |
ASTRAZENECA AB;GREEN, LARRY L.;ZHOU, QING;KEYT, BRUCE, A.;YANG, XIAO-DONG;EMERY, STEPHEN, CHARLES;BLAKEY, DAVID C. |
发明人 |
GREEN, LARRY L.;ZHOU, QING;KEYT, BRUCE, A.;YANG, XIAO-DONG;EMERY, STEPHEN, CHARLES;BLAKEY, DAVID C. |