发明名称 |
Multiblock biodegradable hydrogels for drug delivery and tissue treatment |
摘要 |
Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.
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申请公布号 |
US7250177(B2) |
申请公布日期 |
2007.07.31 |
申请号 |
US20050158565 |
申请日期 |
2005.06.22 |
申请人 |
GENZYME CORPORATION |
发明人 |
PATHAK CHANDRASHEKHAR P.;BARMAN SHIKHA P.;PHILBROOK C. MICHAEL;SAWHNEY AMARPREET S.;COURY ARTHUR J.;AVILA LUIS Z.;KIERAS MARK T. |
分类号 |
A61K9/14;C08G65/32;A61K9/00;A61K9/107;A61K9/127;A61K9/20;A61K9/51;A61K9/70;A61K38/17;A61K47/32;A61K47/34;A61K48/00;A61L15/58;A61L15/60;A61L24/00;A61L24/04;C08F299/02;C08G18/40;C08G63/00;C08G63/672;C08G65/329;C08L51/00;C08L53/00;C08L71/02 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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地址 |
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