发明名称 |
C-25 carbamate rifamycin derivatives with activity against drug-resistant microbes |
摘要 |
Compounds of the current invention relate to rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms. More specifically, compounds of the current invention relate to C-25 carbamate derivatives of rifamycin having another functional group or pharmacophore covalently attached to this position through a carbamate linkage. The resulting compounds exert their antimicrobial activity through a dual-function mechanism and therefore exhibit reduced frequency of resistance.
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申请公布号 |
US7250413(B2) |
申请公布日期 |
2007.07.31 |
申请号 |
US20050114384 |
申请日期 |
2005.04.26 |
申请人 |
CUMBRE PHARMACEUTICALS INC. |
发明人 |
COMBRINK KEITH;HARRAN SUSAN;DENTON DANIEL;MA ZHENKUN |
分类号 |
C07D498/08;A61K31/4709;A61K31/496;A61P31/04;C07D491/14;C07D498/18;C07D519/00 |
主分类号 |
C07D498/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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