| 摘要 |
FIELD: organic chemistry. ^ SUBSTANCE: invention relates to method for synthesis of nitrogen containing heterocyclic compounds, in particular compounds of formula I , wherein 1) R and R1 are H; 2) R is H, R1 is CH3; 3) R and R1 are CH3. Claimed method includes reaction of 2-chloro-3-nitropyridine with 3-R-5-R1-pyridine at 30°C in molar ratio of 1:7 followed by reduction and simultaneous cyclization of produce salt of N-(nitro-2-pyridyl)-3-R-5-R1-pyridinium of general formula II , wherein R and R1 are as defined above, by treatment of alcohol solution of abovementioned salt with SnCl2 solution in hydrochloric acid in molar ratio of N-(nitro-2-pyridyl)-3-R-5-R1-pyridinium salt : SnCl2 = 1:3 at 20°C for 0.12 hours. ^ EFFECT: reduced synthesis cost, decreased time and temperature of process, target product with increased yield and purity. ^ 2 tbl, 6 ex |
