| 发明名称 | 新的β结晶形式的哌林多普利叔丁基胺盐、其制备方法和包含它的药物组合物 | ||
| 摘要 | 本发明涉及β结晶形式的式(I)化合物，其特征在于其粉末X射线衍射图案。本发明可用于制备药物。∴ | ||
| 申请公布号 | CN1328260C | 申请公布日期 | 2007.07.25 |
| 申请号 | CN01812355.4 | 申请日期 | 2001.07.06 |
| 申请人 | 瑟维尔实验室 | 发明人 | B·普法伊费尔;Y－M·吉诺;G·科克雷尔;S·贝耶 |
| 分类号 | C07D209/42(2006.01);A61K31/404(2006.01);A61P9/00(2006.01) | 主分类号 | C07D209/42(2006.01) |
| 代理机构 | 北京市中咨律师事务所 | 代理人 | 刘金辉;林柏楠 |
| 主权项 | 1.β结晶形式的式(I)化合物：<img file="C018123550002C1.GIF" wi="955" he="518" />其特征在于其具有使用衍射仪(铜对阴极)测量并以晶面间距d、布拉格角2θ、强度和相对强度(以相对于最强射线的百分数表达)表达的以下粉末X射线衍射图：<tables id="table1" num="001"><table width="813"><tgroup cols="4"><colspec colname="c001" colwidth="24%" /><colspec colname="c002" colwidth="27%" /><colspec colname="c003" colwidth="20%" /><colspec colname="c004" colwidth="29%" /><thead><row><entry morerows="1"> 2θ角(°)</entry><entry morerows="1"> 晶面间距d(_)</entry><entry morerows="1"> 强度</entry><entry morerows="1"> 相对强度(％)</entry></row></thead><tbody><row><entry morerows="1"> 5.169</entry><entry morerows="1"> 17.08</entry><entry morerows="1"> 523</entry><entry morerows="1"> 16.5</entry></row><row><entry morerows="1"> 8.379</entry><entry morerows="1"> 10.54</entry><entry morerows="1"> 1001</entry><entry morerows="1"> 31.5</entry></row><row><entry morerows="1"> 9.350</entry><entry morerows="1"> 9.45</entry><entry morerows="1"> 3175</entry><entry morerows="1"> 100</entry></row><row><entry morerows="1"> 14.746</entry><entry morerows="1"> 6.00</entry><entry morerows="1"> 236</entry><entry morerows="1"> 7.4</entry></row><row><entry morerows="1"> 15.411</entry><entry morerows="1"> 5.74</entry><entry morerows="1"> 753</entry><entry morerows="1"> 23.7</entry></row><row><entry morerows="1"> 15.931</entry><entry morerows="1"> 5.56</entry><entry morerows="1"> 279</entry><entry morerows="1"> 8.8</entry></row><row><entry morerows="1"> 16.711</entry><entry morerows="1"> 5.30</entry><entry morerows="1"> 113</entry><entry morerows="1"> 3.6</entry></row><row><entry morerows="1"> 18.161</entry><entry morerows="1"> 4.88</entry><entry morerows="1"> 122</entry><entry morerows="1"> 3.8</entry></row><row><entry morerows="1"> 20.564</entry><entry morerows="1"> 4.32</entry><entry morerows="1"> 1198</entry><entry morerows="1"> 37.7</entry></row><row><entry morerows="1"> 21.285</entry><entry morerows="1"> 4.17</entry><entry morerows="1"> 330</entry><entry morerows="1"> 10.4</entry></row><row><entry morerows="1"> 21.781</entry><entry morerows="1"> 4.08</entry><entry morerows="1"> 317</entry><entry morerows="1"> 10</entry></row><row><entry morerows="1"> 22.632</entry><entry morerows="1"> 3.93</entry><entry morerows="1"> 190</entry><entry morerows="1"> 6</entry></row><row><entry morerows="1"> 23.308</entry><entry morerows="1"> 3.81</entry><entry morerows="1"> 133</entry><entry morerows="1"> 4.2</entry></row><row><entry morerows="1"> 23.797</entry><entry morerows="1"> 3.74</entry><entry morerows="1"> 427</entry><entry morerows="1"> 13.4</entry></row><row><entry morerows="1"> 24.276</entry><entry morerows="1"> 3.66</entry><entry morerows="1"> 118</entry><entry morerows="1"> 3.7</entry></row><row><entry morerows="1"> 25.190</entry><entry morerows="1"> 3.53</entry><entry morerows="1"> 92</entry><entry morerows="1"> 2.9</entry></row><row><entry morerows="1"> 25.924</entry><entry morerows="1"> 3.43</entry><entry morerows="1"> 251</entry><entry morerows="1"> 7.9</entry></row><row><entry morerows="1"> 26.646</entry><entry morerows="1"> 3.34</entry><entry morerows="1"> 250</entry><entry morerows="1"> 7.9</entry></row><row><entry morerows="1"> 27.620</entry><entry morerows="1"> 3.23</entry><entry morerows="1"> 96</entry><entry morerows="1"> 3</entry></row><row><entry morerows="1"> 28.306</entry><entry morerows="1"> 3.15</entry><entry morerows="1"> 133</entry><entry morerows="1"> 4.2</entry></row></tbody></tgroup></table></tables> | ||
| 地址 | 法国库伯瓦 | ||