OSMOTIC DOSAGE FORM WITH CONTROLLED RELEASE AND FAST RELEASE ASPECTS

摘要

Disclosed are osmotic dosage forms and methods that provide for fast release of drugs together with controlled release of drugs. In an aspect, disclosed are osmotic dosage forms including: a semi-permeable membrane; a lubricating subcoat located within the semi-permeable membrane; an orifice in the semi-permeable membrane located at an end of the semi-permeable membrane; a drug layer located adjacent to the orifice and within the lubricating subcoat; a push layer located within the lubricating subcoat and on a side of the drug layer opposite from the orifice; wherein an area of the orifice is greater than or equal to about 1 ,600 mil<SUP>2</SUP>; and wherein the drug layer comprises from about 20 wt% to about 90 wt% microcrystalline cellulose, and less than or equal to about 10 wt% of a drug, based on the total weight of the drug layer. Also disclosed are methods of making osmotic dosage forms.