发明名称 Pyrazole-amine compounds for the treatment of neurodegenerative disorders
摘要 The present invention relates to compounds of the Formula wherein R<SUP>1</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP>, R<SUP>6</SUP>, R<SUP>7 </SUP>and R<SUP>8 </SUP>are as defined. Compounds of the Formula I have activity inhibiting production of Abeta-peptide. The invention also relates to pharmaceutical compositions and methods of treating disorders and diseases, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
申请公布号 US7244757(B2) 申请公布日期 2007.07.17
申请号 US20050078861 申请日期 2005.03.11
申请人 PFIZER INC 发明人 CHEN YUHPYNG L.;ZHANG LEI
分类号 A61K31/415;A61K31/4155;A61K31/416;C07D231/16;C07D231/40;C07D405/12 主分类号 A61K31/415
代理机构 代理人
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