| 摘要 |
Provided is a novel compound capable of controlling the activity of various genes and proteins which is effective for treating various diseases through controlling of the energy level in vivo so as to treat and prevent obesity, diabetes, metabolic syndrome, neuro-degenerative diseases and mitochondria dysfunction diseases. The pharmaceutical composition for preventing and treating diseases involving with obesity, diabetes, metabolic syndrome, neuro-degenerative diseases and mitochondria dysfunction diseases comprises a pharmacologically effective amount of a compound represented by the formula(1), a salt thereof, a pro-drug thereof, a solvate thereof or an isomer thereof, and a pharmaceutically acceptable carrier, diluent, excipient or a combination thereof. In the formula, each R1 and R2 is independently H, halogen, alkoxy, hydroxy, or C1-6 lower alkyl, each R3, R4, R5, R6, R7 and R8 is independently H, hydroxy, C1-20 alkyl, alkene or alkoxy, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, or two substitutents among them may bound to each other to form a ring structure, and n is 0 or 1, provided that adjacent carbon atoms may directly bound to each other when n is 0.
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