| 摘要 |
Immunogenic compositions comprising HCV immunogenic polypeptides that cross-neutralize multiple HCV genotypes, as well as methods of using the immunogenic polypeptides are described. In particular, the invention relates to compositions comprising HCV envelope polypeptides that cross-neutralize at least two HCV genotypes selected from HCV-1, HCV-2, HCV-3, HCV-4, HCV-5 and HCV-6. Preferably, the HCV envelope polypeptides cross-neutralize all six of these HCV genotypes. |
