发明名称 |
USE OF MORPHINAN DERIVATES AS MEDICINES |
摘要 |
A method for agonizing or antagonizing the ORL1 (opioid receptor-like) receptor of the nociceptin/orphanin FQ ligand ORL1 receptor system using a morphinan compound of the general formula I or derivatives thereof. Also disclosed are methods for treating neuropathic pain and/or anxiolysis and/or depression and/or diuresis and/or urinary incontinence and/or hypotension and or hypertension and/or senile dementia and/or Alzheimer's disease and/or general cognitive disfunctions an/or tinnitus and/or impaired hearing and/or epilepsy and/or obesity and/or cachexia. |
申请公布号 |
EP1204414(B1) |
申请公布日期 |
2007.07.11 |
申请号 |
EP20000954588 |
申请日期 |
2000.08.04 |
申请人 |
GRUENENTHAL GMBH |
发明人 |
WNENDT, STEPHAN;STRASSBURGER, WOLFGANG;BUSCHMANN, HELMUT;REISSMUELLER, ELKE;KRUEGER, THOMAS |
分类号 |
A61K31/485;C07D489/09;A61P3/06;A61P7/00;A61P7/10;A61P9/00;A61P9/12;A61P13/02;A61P25/00;A61P25/04;A61P25/08;A61P25/22;A61P25/24;A61P25/28;A61P27/16;A61P43/00 |
主分类号 |
A61K31/485 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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