摘要 |
<p>The present invention provides for a process for preparing racemic methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate, its corresponding salt: (2S, 3R, 4S)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate di-p-toluoyl-D-tartaric acid ("D-DTTA") salt or a (2R, 3S, 4R)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate di-p-toluoyl-L-tartaric acid salt ("L-DTTA") in a high enantiomeric excess. This invention also provides for a process for preparing a (2S, 3R, 4S)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate dibenzoyl-D-tartaric acid ("D-DBTA") salt or a (2R, 3S, 4R)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate L-tartaric acid ("L-DBTA") salt in a high enantiomeric excess. Further, this invention provides a process for preparing intermediates II, IIB, III, IV, IV salt, V, VI, and VII.</p> |
申请人 |
SCHERING CORPORATION;WU, GEORGE;CHEN, FRANK, X.;RASHATASAKHON, PAITOON;ECKERT, JEFFREY, M.;WONG, GEORGE, S.;LEE, HONG-CHANG;ERICKSON, NOLAN, C.;VANCE, JENNIFER, ANN;NIRCHIO, PETER, C.;WEBER, JUERGEN;TSAI, DAVID, JIEH-SHYH;NANFEI, ZOU |
发明人 |
WU, GEORGE;CHEN, FRANK, X.;RASHATASAKHON, PAITOON;ECKERT, JEFFREY, M.;WONG, GEORGE, S.;LEE, HONG-CHANG;ERICKSON, NOLAN, C.;VANCE, JENNIFER, ANN;NIRCHIO, PETER, C.;WEBER, JUERGEN;TSAI, DAVID, JIEH-SHYH;NANFEI, ZOU |