摘要 |
This invention provides processes for the preparation of compounds having the structure: wherein X and Y are same or different, and H, OH, OR, SH, SR, NH<SUB>2</SUB>, NHR', or NR'R'' Z is H, F, Cl, Br, I, CN, or NH<SUB>2</SUB>. R is hydrogen, halogen, lower alkyl of C<SUB>1</SUB>-C<SUB>6 </SUB>or aralkyl, NO<SUB>2</SUB>, NH<SUB>2</SUB>, NHR', NR'R'', OH, OR, SH, SR, CN, CONH<SUB>2</SUB>, CSNH<SUB>2</SUB>, CO<SUB>2</SUB>H, CO<SUB>2</SUB>R', CH<SUB>2</SUB>CO<SUB>2</SUB>H, CH<SUB>2</SUB>CO<SUB>2</SUB>R', CH-CHR, CH<SUB>2</SUB>CH-CHR, or C-CR. R' and R'' are same or different, and lower alkyl of C<SUB>1</SUB>-C<SUB>6</SUB>. R<SUP>13 </SUP>is hydrogen, alkyl, acyl, phosphate (monophosphate, diphosphate, triphosphate, or stabilized phosphate) or silyl; and<img id="custom-character-00001" he="2.56mm" wi="46.20mm" file="US20050090660A1-20050428-P00999.TIF" alt="text missing or illegible when filed" img-content="character" img-format="tif"/> |