ALPHA ENOLASE-DIRECTED DIAGNOSTICS AND THERAPEUTICS FOR CANCER AND CHEMOTHERAPEUTIC DRUG RESISTANCE

摘要

Disclosed are methods for detecting a neoplasm and/or chemotherapeutic drug resistance or angiogenic potential in neoplastic cells by detecting an increase in the expression of a-enolase in such cells, or in the case of metastatic potential on the surface of such cells, as compared to the level of expression of a-enolase protein in a normal or non-MDR neoplastic cell or on the surface of a non-metastatic neoplastic cell. In addition, methods and a composition are disclosed for increasing the sensitivity of a neoplasm to a chemotherapeutic drug treatment regime, for inhibiting angiogenesis and metastatic potential in chemotherapeutic drug resistant or neoplastic cells, and for inducing apoptosis in chemotherapeutic drug resistant or neoplastic cells.