Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof
摘要
The present invention is directed generally to recombinant methods for making a desired pegylated protein and pooling of same. These method(s) yield a polypeptide product containing reduced levels of aggregate thereof pooled to provide the desired pegylated isoforms thereof.
申请公布号
ZA200501841(B)
申请公布日期
2007.06.27
申请号
ZA20050001841
申请日期
2003.08.26
申请人
PHARMACIA CORPORATION
发明人
RATHORE, ANURAG S;LYLE, STEPHEN B;STEINMEYER, DAVID E;ALLEN, SCOTT I;MEYER, JOHN;BOYLE, DENIS M.;BUCKLEY, JOHN J.;JOHNSON, GARY V.