Therapeutic quinazoline derivatives

摘要

A compound of formula (I) or a salt, ester, amide or prodrug thereof; where X is O, or S, S(O), S(O)₂ or NR⁶ where R⁶ is hydrogen of C_1-6alkyl; R⁵ is an optionally substituted 6-membered aromatic ring containing at least one nitrogen atom, and R¹, R², R³, R⁴ are independently selected from halogeno, cyano, nitro, C_1-3alkylsulphanyl, -N(OH)R⁷- (wherein R⁷ is hydrogen, or C_1-3alkyl), or R⁹X¹- (wherein X¹ represents a direct bond, -O-, -CH₂-, -OC(O), -C(O)-, -S-, -SO-, -SO₂-, -NR¹⁰C(O)-, -C(O)NR¹¹-, -SO₂NR¹²-, -NR¹³SO₂- or NR¹⁴- (wherein R¹⁰, R¹¹, R¹², R¹³ and R¹⁴ each independently represents hydrogen, C_1-3alkyl or C_1-3alkoxyC_2-3alkyl), and R⁹ is hydrogen, optionally substituted hydrocarbyl, optionally substituted heterocyclyl or optionally substituted alkoxy; provided that at least one of R² or R³ is other than hydrogen. These compounds inhibit aurora 2 kinase and are useful in the preparation of medicaments for the treatment of proliferative disease such as cancer.