Sandwich sensor for determining the concentration of an analyte

摘要

The implantable sensor for a continuous determination of a concentration of an analyte in a body tissue and/or a body fluid, exhibits a gradated layered structure exhibiting an isolating substrate base and two electrodes comprising a working electrode (144), a counter electrode (140) and/or reference electrode (142). The substrate base comprises an electrically non-conductive material and the electrodes are arranged in different layer steps of the layered structure. A biocompatible membrane layer (146) partly or completely encloses the two electrodes. The implantable sensor for a continuous determination of a concentration of an analyte in a body tissue and/or a body fluid, exhibits a gradated layered structure exhibiting an isolating substrate base and two electrodes comprising a working electrode (144), a counter electrode (140) and/or reference electrode (142). The substrate base comprises an electrically non-conductive material and the electrodes are arranged in different layer steps of the layered structure. A biocompatible membrane layer (146) partly or completely encloses the two electrodes. Two electrode contact layers electrically contact the two electrodes. The substrate base exhibits a width, in which the two electrodes and/or the two electrode contact layers extend themselves essentially over the entire width of the isolating substrate base. The two electrode contact layers are electrically isolated from the body tissue and/or the body fluid by self-adhesive foil layers. The membrane layer exhibits a partial permeability for the analyte. The counter electrode and the reference electrode are formed as a common electrode. A tapered injection point is used for piercing the implantable sensor into a fat tissue. The substrate base and/or the implantable sensor exhibit a width B and a height H, in which the ratio H/B or its reciprocal value defines an aspect ratio k, which is 0.9. The substrate base forms a step-like structure. An electrode is intended in a single level of the step-like structure. The isolating substrate base is embedded between a first electrode contact layer and a second electrode contact layer. The two electrodes are applied on the side of the two electrode contact layers turned away from the isolating substrate base. Independent claims are included for: (1) a device for a continuous determination of a concentration of an analyte in a body tissue and/or a body fluid; and (2) a procedure for production of implantable sensor.