Use of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide for preparing products as bacterial virulence inhibitors for the manufacture e.g. of drugs for veterinary use to treat/prevent bacterial infections

摘要

#CMT# #/CMT# 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide (I) and its derivatives is used for preparation of products such as bacterial virulence inhibitors. #CMT#ACTIVITY : #/CMT# Antibacterial. #CMT#MECHANISM OF ACTION : #/CMT# Bacterial virulence inhibitor. Tests details are described but no results given. #CMT#USE : #/CMT# (I) is useful for the manufacture of: speciality chemicals used in human medicine; drugs for veterinary use; food supplements for animal use; and phytosanitary products, to treat or prevent bacterial infections (all claimed). #CMT#ADVANTAGE : #/CMT# (I) does not inhibit growth or mobility of the bacteria but reduces their cytotoxic capacity by apoptosis and causes an increase in their absorbent character, prevents the bacterial infection and decreases the total virulence character. #CMT#PHARMACEUTICALS : #/CMT# Preferred Components: The molecules of (I) are used in combination with antibiotic active molecules.