发明名称 |
Fusion proteins comprising bacteriophage coat protein and asingle-chain T cell receptor |
摘要 |
The present invention relates to novel fusion proteins comprising a bacteriophage coat protein and a single-chain T cell receptor and uses of such complexes. In one aspect, the invention relates to soluble fusion protein comprising a bacteriophage coat protein covalently linked to a single-chain T cell receptor which comprises a V-alpha chain covalently linked to a V-beta chain by a peptide linker sequence. The soluble fusion proteins of the invention are useful for a variety of applications including: 1) making a bacteriophage library for displaying single-chain T cell receptors for use in screens for identification and isolation of ligands that bind single-chain T cell receptors, and 2) methods for isolating soluble and fully functional single-chain T cell receptors from the fusion proteins.
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申请公布号 |
US2007116718(A1) |
申请公布日期 |
2007.05.24 |
申请号 |
US20060455225 |
申请日期 |
2006.06.15 |
申请人 |
ALTOR BIOSCIENCE CORPORATION |
发明人 |
WEIDANZ JON A.;CARD KIMBERLYN F.;WONG HING C. |
分类号 |
A61K39/12;C07H21/04;C07K14/005;C07K14/01;C07K14/705;C07K14/725;C12N7/01;C12N15/10;C12N15/86;C12P21/04;C40B40/02 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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