发明名称 |
Composition and methods relating to DNA mismatch repair genes |
摘要 |
Genomic sequences of human mismatch repair genes are described, as are methods of detecting mutations and/or polymorphisms in those genes. Also described are methods of diagnosing cancer susceptibility in a subject, and methods of identifying and classifying mismatch-repair-defective tumors. In particular, sequences and methods relating to human mutL homologs, hMLH1 and hPMS1 genes are provided.
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申请公布号 |
US6165713(A) |
申请公布日期 |
2000.12.26 |
申请号 |
US19970961810 |
申请日期 |
1997.10.31 |
申请人 |
OREGON HEALTH SCIENCES UNIVERSITY;DANA-FARBER CANCER INSTITUTE |
发明人 |
LISKAY, ROBERT M.;BRONNER, C. ERIC;BAKER, SEAN M.;BOLLAG, RONI J.;KOLODNER, RICHARD D. |
分类号 |
G01N33/50;C07H21/04;C07K14/47;C12N15/09;C12P21/08;C12Q1/68;G01N33/53;G01N33/566;(IPC1-7):C12Q1/68;C12P19/34 |
主分类号 |
G01N33/50 |
代理机构 |
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