发明名称 |
AAV structural protein, production and use thereof |
摘要 |
<p>Structural proteins of adeno-associated virus (AAV) with at least one mutation are new and have an increased infectiveness. Independent claims are also included for: (1) structure proteins as described above in the form of AAV-particles, especially AAV-capsids; (2) nucleic acids encoding the structure proteins; (3) cells comprising (2); (4) preparation of the structure proteins, comprising culturing the cells of (3) and isolating the expressed proteins; (5) pharmaceutical compositions comprising (2) and/or (3); (6) a diagnostic agent comprising (2) and/or (3); and (7) use of the structure protein for altering the tropism of AAV for the transformation of a cell, for the diagnostic, for effectivity studies for gene therapy and/or for genomic targeting.</p> |
申请公布号 |
EP1783225(A1) |
申请公布日期 |
2007.05.09 |
申请号 |
EP20060018532 |
申请日期 |
1999.06.21 |
申请人 |
MEDIGENE AG |
发明人 |
HALLEK, MICHAEL;RIED, MARTIN;DELEAGE, GILBERT;GIROD, ANNE |
分类号 |
C12N15/35;G01N33/68;A61K38/00;A61K39/23;A61K48/00;A61P31/12;C07K14/015;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/62;C12P21/02 |
主分类号 |
C12N15/35 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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