发明名称 |
Methods for treating ICACC protein associated diseases |
摘要 |
A new gene in the calcium-activated chloride channel family has been discovered that is induced by IL-9, thereby providing a therapeutic target in IL-9 mediated development of atopic allergy, asthma-related disorders and cystic fibrosis. A method for the identification and use of small molecule inhibitors of this gene and its products to treat these disorders has also been discovered. The invention also includes a method for diagnosing susceptibility to, and assessing treatment of atopic allergy, asthma-related disorders by measuring the level of gene expression in biologic samples using antibody specific for this protein.
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申请公布号 |
US7211254(B2) |
申请公布日期 |
2007.05.01 |
申请号 |
US20040772437 |
申请日期 |
2004.02.06 |
申请人 |
GENAERA CORPORATION |
发明人 |
HOLROYD KENNETH J.;LEVITT ROY C.;MALOY W. LEE;LOUAHED JAMILA;MCLANE MIKE;NICOLAIDES NICHOLAS C.;ZHOU YUHONG;DONG QU |
分类号 |
A61K39/395;G01N33/53;A61K31/7088;A61K38/00;A61K38/20;A61K45/00;A61P1/00;A61P11/00;A61P11/06;A61P37/08;A61P43/00;C07H21/04;C07K14/705;C12N15/09;C12N15/12;C12P21/08;G01N33/68 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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