NOVEL FGF RECEPTOR BINDING COMPOUNDS COMPRISING PEPTIDE FRAGMENTS OF NEURAL CELL ADHESION MOLECULE L1

摘要

The present invention relates to novel peptide compounds capable of interacting with Fibroblast Growth Factor Receptor (FGFR) comprising an amino acid sequence of 5 to 105 amino acid residues which comprises an amino acid motif of the formula x'-(x)_n-x^p-(x)_n-x' , wherein x' is a basic amino acid residue, x^p is a hydrophobic amino acid residue and (x)_n is a sequence of any amino acid residues, wherein n is an integer from 0 to 3. Preferably, the compounds of the invention comprise a fragment of neural cell adhesion molecule L1. The invention also relates to uses of the compounds for treatment and/or prevention of different pathological conditions wherein FGFR and /or L1 play a role in pathology and/or recovery from the disease. Accordingly, pharmaceutical compositions comprising the compounds of the invention are also concerned.-