发明名称 |
COMPOSITIONS INHIBITING SMOOTH MUSCLE PROLIFERATION AND METHOD FOR THE DIAGNOSIS OF ARTERIOSCLEROSIS |
摘要 |
<p>The invention provides not only a smooth muscle growth inhibitory composition and a composition for inhibiting expression of adhesion molecules in vascular endothelial cells, each comprising the adipose tissue-specific secretory factor apM1 as an active ingredient, but also a method for diagnosis of arteriosclerosis which comprises assaying apM1 in a sample, an antibody against apM1, and a diagnostic kit for arteriosclerosis which comprises the antibody as an active component, all of which contribute to the elucidation of obesity-related genes and corresponding expression products which are useful for the etiologic exploration and establishment of therapeutic modalities for various obesity-related diseases, particularly arteriosclerosis inclusive of angina pectoris and myocardial infarction. By utilizing the information thus obtained, therapeutic and diagnostic methods for various diseases can be established.</p> |
申请公布号 |
EP1033134(B1) |
申请公布日期 |
2007.04.25 |
申请号 |
EP19980950411 |
申请日期 |
1998.10.27 |
申请人 |
OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
MATSUZAWA, YUJI;OHMOTO, YASUKAZU |
分类号 |
A61K38/17;A61K38/00;A61K38/22;A61P9/10;C07K14/575;C07K16/18;C07K16/26;C12N5/12;C12N15/08;C12P21/08;C12R1/91;G01N33/50;G01N33/53;G01N33/577;G01N33/68 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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