Orally administered small peptides synergize statin activity
摘要
This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis. The peptides are highly stable and readily administered via an oral route. The peptides are effective to stimulate the formation and cycling of pre-beta high density lipoprotein-like particles and/or to promote lipid transport and detoxification. This invention also provides a method of tracking a peptide in a mammal. In addition, the peptides inhibit osteoporosis. When administered with a statin, the peptides enhance the activity of the statin permitting the statin to be used at significantly lower dosages and/or cause the statins to be significantly more anti-inflammatory at any given dose.
申请公布号
ZA200601638(B)
申请公布日期
2007.04.25
申请号
ZA20060001638
申请日期
2006.02.24
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;THE UAB RESEARCH FOUNDATION