| 主权项 |
1. A compound of Formula (II):or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein:
ring A is independently selected from the group consisting of: C3-14 carbocycle and a 4- to 14-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, NRe, O, and S(O)p; wherein said carbocycle and heterocycle are further substituted with 0-4 R5; X1 is independently selected from the group consisting of: a bond, a hydrocarbon linker and a hydrocarbon-heteroatom linker; wherein said hydrocarbon linker and hydrocarbon-heteroatom linker may be substituted with 0-2 Rg; said hydrocarbon linker has one to six carbon atoms and may be saturated or unsaturated; and said hydrocarbon-heteroatom linker may be saturated or unsaturated and has zero to four carbon atoms and one group selected from O, —CO—, S, —SO—, —SO2—, NH, N(C1-4 alkyl), —NHCO—, —CONH—, —OCONH—, —NHCONH—, and —SO2NH—; L is independently a hydrocarbon linker substituted with 0-2 Rg or a hydrocarbon-heteroatom linker substituted with 0-2 Rg; wherein said hydrocarbon linker has one to eight carbon atoms and may be straight or branched, saturated or unsaturated; and said hydrocarbon-heteroatom linker has one to seven carbon atoms and one group selected from O, —CO—, S, —SO—, —SO2—, NH, N(C1-4 alkyl), and —NHCO—; R1 and R3 are each independently selected from the group consisting of: H, C1-6 haloalkyl, C1-6 alkyl substituted with 0-3 Ra, C2-6 alkenyl substituted with 0-3 Ra,and —(CH2)n—(C3-10 carbocycle substituted with 0-3 Rc);
R4 is independently selected from the group consisting of: H, ═O, halogen, C1-6 alkyl substituted with 0-1 OH, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, CN, NO2, NH2, N(C1-4 alkyl)2, and a ring moiety substituted with 0-2 Rh and selected from: C3-10 carbocycle and a 5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, NRe, O, and S(O)p; R5 is, independently at each occurrence, selected from the group consisting of: ═O, OH, halogen, C1-6 alkyl substituted with 0-1 OH, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, SCF3, CN, NH2, NO2, NH(C1-4 alkyl), N(C1-4 alkyl)2, CO2H, CO2(C1-4 alkyl), —CH2CO2(C1-4 alkyl), CO(C1-4 alkyl), CONH2, CONH(C1-4 alkyl), and CON(C1-4 alkyl)2; R7 is independently selected from the group consisting of: H, COCF3, C1-6 haloalkyl, C1-6 alkyl substituted with 0-1 Ra, —(CHRf)n—(C3-10 carbocycle substituted with 0-3 Rb), and —(CHRf)n—(5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, NRe, O, and S(O)p); and wherein said heterocycle is substituted with 0-3 Rc; Ra is, independently at each occurrence, selected from the group consisting of: halogen, OH, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, CN, NH2, NO2, NH(C1-4 alkyl), N(C1-4 alkyl)2, CO2H, CO2(C1-4 alkyl), NHCO(C1-4 alkyl substituted with 0-1 NH2), N(C1-4 alkyl)CO(C1-4 alkyl), NHCO2(C1-4 alkyl), CONHSO2(C1-4 alkyl), SO2(C1-4 alkyl), CONH2, CONH(C1-4 alkyl), NHSO2(C1-4 alkyl), N(C1-4 alkyl)SO2(C1-4 alkyl), phenoxy, and —CONH(phenylcyclohexyl); Rb is, independently at each occurrence, selected from the group consisting of: halogen, OH, C1-4 alkyl substituted with 0-1 OH, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, CN, NH2, NO2, NH(C1-4 alkyl), N(C1-4 alkyl)2, CO2H, CO2(C1-4 alkyl), CONH2, CONH(C1-4 alkyl), CON(C1-4 alkyl)2, NHCO2(C1-4 alkyl), NHSO2(C1-4 alkyl), N(C1-4 alkyl)SO2(C1-4 alkyl), SO2(C1-4 alkyl), SO2NH2, phenyl, benzyl, and phenoxy; Rc is, independently at each occurrence, selected from the group consisting of: ═O and Rb; Rd is, independently at each occurrence, selected from the group consisting of: CONH2, C1-4 alkyl, —(CH2)2O(CH2)2O(C1-4 alkyl), C3-6 carbocycle substituted with 0-2 Rh, morpholin-1-yl, 1-C1-4 alkyl-piperazin-4-yl, 1-CBz-piperazin-4-yl, pyridyl, indol-3-yl, and benzothiazol-2-yl; Re is, independently at each occurrence, selected from the group consisting of: H, C1-4 alkyl, CO(C1-4 alkyl), CO2(C1-4 alkyl), CO2(benzyl), CONH(C1-4 alkyl), CONH(phenyl substituted with 0-2 halogens), SO2(C1-4 alkyl), and —(CH2)nRd; Rf is, independently at each occurrence, selected from the group consisting of: H and C1-4 alkyl; Rg is, independently at each occurrence, selected from the group consisting of: halogen, OH, C1-4 alkyl, C2-4 alkenyl, C1-4 haloalkyl, C1-4 alkyoxy, CO2(C1-4 alkyl), C3-6 cycloalkyl, and phenyl; Rh is, independently at each occurrence, selected from the group consisting of: H, halogen, C1-6 alkyl, C1-6 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, —(CH2)2O(C1-4 alkyl), CF3, NO2, CONH2, OBn, quinolinyl, 1-C1-4 alkyl-pyrazolyl, 1-(CH2CO2(C1-4 alkyl))-pyrazolyl, 1-C1-4 alkyl-3-CF3-pyrazolyl, 1-((CH2)2(morpholin-4-yl))-pyrazolyl, 1-(tetrahydro-2H-pyran-2-yl)-pyrazolyl, 1,2,5-triC1-4 alkyl-pyrazolyl, 2-Ph-4-C1-4 alkyl-thiazolyl, —NHSO2(phenyl substituted with C1-4 alkyl), and —(CH2)0-2-(phenyl substituted with zero to three substituents independently selected from the group consisting of: halogen, CH2OH, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, N(C1-4 alkyl)2, CONH2, and NHCO(C1-4 alkyl)); n is, independently at each occurrence, selected from 0, 1, 2, 3, and 4; and p is, independently at each occurrence, selected from 0, 1, and 2; provided that the following compound is excluded: |
