MODIFYING TISSUE SURFACES BY LIQUID CRYSTAL FORMATION

摘要

A method for modifying the surface properties of tissue in vivo is described . The method comprises forming a liquid crystalline matrix on the tissue surface wherein the matrix comprises a tissue surface component. In one embodiment there is provided a method for improving the bonding of surgical glues and cements to cartilage and oth er synovial fluid wetted tissue surfaces. Such surfaces are contacted with a composition comprising a poly(hydroxy substituted amino aci d) to form a liquid crystalline matrix on the tissue surface. The matrix is readily removed to provide a tissue surface that exibits improved bonding with surgical glues.