DRUG DELIVERY NANOCARRIERS TARGETED BY LANDSCAPE PHAGE

摘要

A targeted drag delivery nanocarrier and a method of forming the same is disclosed herein. The targeted drag delivery nanocarrier includes a plurality of amphipathic molecules forming a carrier particle having a plurality of drag molecules contained therein. A targeted landscape phage protein assembly is complexed to the carrier particle preferably using the unique method disclosed herein. The targeted landscape phage protein assembly displays a binding peptide that is selected to specifically and selectively bind to a target site. The method for forming targeted drag delivery nanocarriers includes the steps of obtaining a plurality of bacteriophage displaying a binding peptide for a desired target site, treating the bacteriophage with a denaturing agent, mixing the treated bacteriophage with a plurality of carrier particles and purifying the mixture to obtain a plurality of targeted drag delivery nanocarriers.