发明名称 |
COMPOSITIONS AND METHODS FOR TREATMENT OF NEURAL DISORDERS USING TRANSFORMING GROWTH FACTOR-BETA SUPERFAMILY PROTEINS AND THEIR ANTAGONISTS |
摘要 |
Contemplated compositions and methods employ a TGF-beta superfamily protein or antagonist thereof to treat a neural disorder characterized by an imbalance in differentiated functional sensory and neural cells derived from a sensory/neural progenitor cell. Preferably, GDF-11 and/or antagonists thereof are employed in the treatment of diseases in which visual and/or auditory progenitor cells will provide for a repair mechanism to the disease. Most preferably, GDF-11 is employed as a modulator of competency to increase production of retinal ganglion cells, retinal photoreceptors, retinal amacrine cells, sensory hair and supporting cells of the vestibulocochlear epithelium, and/or neurons and supporting cells of the spiral acoustic ganglion and vestibulo-cochlear (auditory) nerve to which it gives rise.
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申请公布号 |
WO2006128190(B1) |
申请公布日期 |
2007.04.05 |
申请号 |
WO2006US21016 |
申请日期 |
2006.05.30 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;CALOF, ANNE, L.;KIM, JOON;KAWAUCHI, SHIMAKO |
发明人 |
CALOF, ANNE, L.;KIM, JOON;KAWAUCHI, SHIMAKO |
分类号 |
A61K38/00 |
主分类号 |
A61K38/00 |
代理机构 |
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主权项 |
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地址 |
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