发明名称 |
A PROCESS FOR THE PREPARATION OF ZOFENOPRIL CALCIUM SALT |
摘要 |
A process for the preparation of polymorph A of zofenopril calcium salt in substantially pure form, which comprises: 1) reaction of S(-)-3-benzoylthio-2-methylpropanoic acid chloride with cis-4-phenylthio-L-proline in water at pH ranging from 9.0 to 9.5 and recovery of zofenopril in the acidic form; b) salification of acid zofenopril with a poyassium salt in alcoholic solution, and recovery of the resulting potassium salt; c) conversion of the potassium salt to the calcium salt by addition of zofenopril potassium salt aqueous solution to a CaCl2 aqueous solution at a temperature of 70-90° C. with simultaneous seeding to promote the precipitation of polymorph A. |
申请公布号 |
PL193828(B1) |
申请公布日期 |
2007.03.30 |
申请号 |
PL19990345814 |
申请日期 |
1999.07.30 |
申请人 |
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG SA |
发明人 |
GIORGI RAFFAELLO;GIACHETTI ANTONIO;MANNUCCI CARLO;FALEZZA ANITA |
分类号 |
C07D207/16;A61K31/40;A61K31/401;A61P9/04;A61P9/10;A61P9/12 |
主分类号 |
C07D207/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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