| 摘要 |
#CMT# #/CMT# Phenylazo phenyl acetamide compound (I), is new. #CMT# : #/CMT# Phenylazo phenyl acetamide compound of formula (I), is new. R, R-a : 1-4C (hydroxy)alkyl; i, j : 0-4; and R1, R 1, R2, R 2H or CH 3. Independent claims are included for: (1) the preparation of (I); (2) a polymerizable yellow dye comprising (I); (3) a polymerizable composition and/or radical crosslinkable 4-chloromethylstyrene comprising a polymer precursor matrix and the dye at 0.02-0.15 wt.%; (4) a colored polymer matrix obtained by copolymerization, radical crosslinking and/or crosslinking polymerization of the composition; and (5) an intraocular lenses having an optic and haptic properties comprising the colored polymer matrix. #CMT#[Image]#/CMT# #CMT#USE : #/CMT# (I) is useful to prepare the colored polymer matrix, which is useful to prepare intraocular lenses (claimed). #CMT#ADVANTAGE : #/CMT# (I) is simple and easy to disperse to form the matrix and provides stable and strong products. #CMT#ORGANIC CHEMISTRY : #/CMT# Preparation (Claimed): Preparation of (I) comprises reacting N-[4-(2-hydroxy-5-methyl-phenylazo)-phenyl]-acetamide compound of formula (II) with a styrenic derivative of formula (III) in the presence of an alkaline polar aprotic solvent, where the styrene derivative intervenes in stoichiometric excess. Y 1alkyl or 1-4C hydroxyalkyl; z : 0-4; and Y 2, Y 3H or methyl. Preferred Process: (III) intervenes in a quantity such as twice the stoichiometric quantity, preferably 3 times the stoichiometric quantity. Preferred Components: The styrenic derivative is 4-chloromethylstyrene. The precursor mixture contains a polymerization initiator and/or crosslinking agent and ultraviolet absorber i.e. preferably copolymerizable. #CMT#[Image]#/CMT# #CMT#POLYMERS : #/CMT# Preferred Components: The precursor mixture is polysiloxane or acrylic monomers. The acrylic monomers form a hydrophilic or hydrophobic matrix. The acrylic monomers comprise 2-hydroxyethyl methacrylate and alkyl (meth)acrylate or hydroxyalkyl (having 1-8 carbon atoms). The acrylic monomers comprise a mixture of: 2-hydroxyethyl methacrylate and methyl methacrylate; 2-hydroxyethyl methacrylate and ethyl methacrylate; or 2-hydroxyethyl methacrylate and 6-hydroxyhexyl methacrylate. The acrylic monomer is of formula (R 1>-C(=CH 2)-C(=O)-O-R-b). R 1>H or methyl; and R-b : 1-5C alkyl-phenyl. #CMT#SPECIFIC COMPOUNDS : #/CMT# 1 Compound (I) is specifically claimed i.e. N-[4-[5-methyl-2-(4-vinyl-benzyloxy)-phenylazo]-phenyl]-N-(4-vinyl-benzyl)-acetamide of formula (Ia). #CMT#EXAMPLE : #/CMT# C.I Disperse Yellow-3 was stirred with dimethylformamide (50 ml) for 1 hour to give a mixture. Potash (0.32 g) was agitated with mixture for 40 minutes. 4-Chloromethylstyrene was added to the obtained mixture and stirred for 42 hours. Ionized water (100 ml) was added to the mixture to give (N-{4-[5-methyl-2-(4-vinyl-benzyloxy)-phenylazo]-phenyl}-N-(4-vinyl-benzyl)-acetamide) monomer. The monomer was extracted using ether. The obtained organic phase was washed 5 for times with ionized water (100 ml), dried on sodium sulfate and the solvent was evaporated. The monomer was recrystallized in the dried ether and sodium sulfate. |
