摘要 |
The invention relates to the medical use of natural isoflavones and their semisynthetic derivatives or the pharmaceutically acceptable salts thereof for the therapeutic and/ or prophylactic treatment of diseases, at the base of which lies an excessive production or storage of glycosaminoglycans, especially for treatment of mucopolysaccharidoses. The isoflavones and their semisynthetic derivatives are represented by formula (I), in which R<SUB>1</SUB> and R<SUB>2</SUB> are the same or different and are independently H or alkyl, alkenyl, aryl alkylaryl, alkylcarbonyl, arylcarbonyl or mono-, di- or oligosaccharide group, each of then optionally substituted by at least one acyl, alkyl, cycloalkyl, alkoxyalkyl, aryl, alkylaryl, carboxyl or cyano; and R<SUB>3</SUB> is H, acyl or alkyl. |
申请人 |
INSTYTUT FARMACEUTYCZNY;GRYNKIEWICZ, GRZEGORZ;WEGRZYN, GRZEGORZ;SZECHNER, BARBARA;SZEJA, WIESLAW;TYLKI-SZYMANSKA. ANNA;WEGRZYN, ALICJA;JAKOBKIEWICZ-BANECKA, JOANNA;BARANSKA, SYLWIA;CZARTORYSKA, BARBARA;PIOTROWSKA, EWA |
发明人 |
GRYNKIEWICZ, GRZEGORZ;WEGRZYN, GRZEGORZ;SZECHNER, BARBARA;SZEJA, WIESLAW;TYLKI-SZYMANSKA. ANNA;WEGRZYN, ALICJA;JAKOBKIEWICZ-BANECKA, JOANNA;BARANSKA, SYLWIA;CZARTORYSKA, BARBARA;PIOTROWSKA, EWA |