发明名称 |
METHODS AND COMPOSITIONS COMPRISING SUPRAMOLECULAR CONSTRUCTS |
摘要 |
<p>The present invention comprises novel compositions and methods for eliciting high immune responses, of great specificity yielding conformationally sensitive antibodies. These antibodies recognize specific epitopes on a wide variety of antigens including but not limited to, amyloid protein, prion protein, P 170 glycoprotein. The novel compositions of the invention comprise surpamolecular antigenic constructs generally comprising a peptide sequence, covalently attached to pegylated lysine resulting in modified and enhanced peptide presentation. The unique modification methodology of the present invention is applicable to a variety of peptides and can ultimately be employed in therapeutic formulations and vaccines for diseases and disorders such as Alzheimer's disease.</p> |
申请公布号 |
EP1763364(A2) |
申请公布日期 |
2007.03.21 |
申请号 |
EP20050723323 |
申请日期 |
2005.02.22 |
申请人 |
AC IMMUNE S.A. |
发明人 |
NICOLAU, CLAUDE YVES;GREFERATH, RUTH, DR.;HICKMAN, DAVID |
分类号 |
A61K39/385;A61K39/00;A61K39/39;C07K14/47;C07K16/18 |
主分类号 |
A61K39/385 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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