摘要 |
Dipeptidyl peptidase IV (DPP-IV)-inhibiting compounds are provided that have formula I: wherein n is 1 to 3; X is CH<SUB>2</SUB>; S; O; CF<SUB>2 </SUB>or C(CH<SUB>3</SUB>)<SUB>2</SUB>; Z is H; halogen; hydroxyl; (C<SUB>1-6</SUB>)alkoxy; (C<SUB>1-12</SUB>)alkyl; (C<SUB>3-12</SUB>)cycloalkyl; phenyl; or heteroaryl; where the phenyl and heteroaryl groups are optionally mono- or independently plurisubstituted with R7; optionally, X together with an adjacent ring carbon and Z form a fused cyclopropyl; and optionally, one of the bonds in the ring containing X is a double bond; and Cr<SUP>i</SUP>R<SUP>ii</SUP>, R<SUP>1</SUP>, R<SUP>1</SUP>, R<SUP>3</SUP>, R<SUP>4 </SUP>and R<SUP>5 </SUP>are as described herein. Methods for preparing these compounds, and methods for treating diabetes, especially Type II diabetes, and other related diseases are described using the compounds of formula I in pharmaceutical compositions which contain these compounds. Pharmaceutical compositions which contain combinations of these compounds with other antidiabetic agents are also described herein.
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