发明名称 |
SYSTEM UND VERFAHREN ZUR HERSTELLUNG ARZNEISTOFFBELADENER MIKROPARTIKEL |
摘要 |
Method and system of producing microparticles loaded with biologically active drugs, including proteins such as ICAM-1, for controlled release of the drugs in a nasal passageway. The method includes introducing a drug/polymer feed solution and an emulsifier into a first mixing chamber to create an emulsion, then mixing a cross-linking agent together with the emulsion under controlled conditions to create microparticles loaded with the drug. The system includes a first mixing chamber, in which the emulsion is created, having a first port for introducing the drug/polymer solution, and a second port angled substantially perpendicular to the first port for introducing the emulsifier. A second mixing chamber adjacent to the first mixing chamber receives the emulsion and either contains a cross-linking agent or receives a stream of a cross-linking agent to solidify the microparticles. The formed microparticles are filtered and deaggregated to form individual microparticles that then may be formulated for nasal passageway delivery. |
申请公布号 |
AT353631(T) |
申请公布日期 |
2007.03.15 |
申请号 |
AT19960918456T |
申请日期 |
1996.06.06 |
申请人 |
SRI INTERNATIONAL |
发明人 |
BOMBERGER, DAVID, C.;CATZ, PAUL, G.;SMEDLEY, MARK, I.;STEARNS, PAUL, C. |
分类号 |
A61K9/14;A61K9/16;A61K38/00;A61K38/17;A61K39/00;B01J2/00;(IPC1-7):A61K9/14 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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