摘要 |
<p>The present invention pertains to certain 1,5-substituted-1H-tetrazole compounds that, inter alia, inhibit 11ß- hydroxysteroid dehydrogenase type 1 (11ß-HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, bothin vitro and in vivo, to inhibit 11ß-hydroxysteroid dehydrogenase type 1; to treat conditions that are ameliorated by the inhibition of 11ß-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes conditions such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS conditions such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.</p> |
申请人 |
THE UNIVERSITY OF EDINBURGH;WEBSTER, SCOTT, PETER;SECKL, JONATHAN, ROBERT;WALKER, BRIAN, ROBERT;WARD, PETER;PALLIN, THOMAS, DAVID;DYKE, HAZEL, JOAN |
发明人 |
WEBSTER, SCOTT, PETER;SECKL, JONATHAN, ROBERT;WALKER, BRIAN, ROBERT;WARD, PETER;PALLIN, THOMAS, DAVID;DYKE, HAZEL, JOAN |