BIODEGRADABLE MICROPARTICLE PHARMACEUTICAL FORMULATIONS EXHIBITING IMPROVED RELEASE RATES

摘要

This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus (100) includes a spinning disk (105) containing a reservoir (708) in the center thereof and a flat inclined surface. The apparatus optionally includes serrations (712) and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.