2, 4,6-TRISUBSTITUTED PYRIMIDINES AS PHOSPHOTIDYLINOSITOL (PI) 3-KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF CANCER.

摘要

The invention concerns pyrimidine derivatives of Formula (I) wherein each ofp, R1, R2, q, R3, r, R4, X1and Q1 have any of the meanings defined in the description; processesfor their preparation, pharmaceutical compositions containing them and theiruse in the manufacture of a medicament for use in the production of an anti-proliferativeeffect in a warm-blooded animal such as man.