发明名称 |
Compounds that regulate apoptosis |
摘要 |
Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing or preventing apoptosis are described, together with methods for identifying molecules that induce or prevent apoptosis through interaction with Bcl-2-family members. Methods for treatment of proliferative diseases and neurodegenerative diseases using the modulators of Bcl-2 and related family members are also disclosed.
|
申请公布号 |
US2007054863(A1) |
申请公布日期 |
2007.03.08 |
申请号 |
US20060433783 |
申请日期 |
2006.05.11 |
申请人 |
SATTERTHWAIT ARNOLD;ZHANG XIAO-KUN;ZHU XIUWEN;KOLLURI SIVA |
发明人 |
SATTERTHWAIT ARNOLD;ZHANG XIAO-KUN;ZHU XIUWEN;KOLLURI SIVA |
分类号 |
A61K38/10;A61K38/08;C07K7/06;C07K7/08 |
主分类号 |
A61K38/10 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|