发明名称 |
METHOD OF PREPARING PROPIONIC ACID-TERMINATED POLYMERS |
摘要 |
The invention provides methods for preparing polymers bearing a terminal propionic acid. The method involves first reacting a water soluble and non-peptidic polymer comprising at least one hydroxyl group with a tertiary alkyl acrylate in the presence of a catalyst to form a propionic acid ester of the polymer, wherein the polymer has a weight average molecular weight of at least about 10,000 Da; and then treating the propionic acid ester of the polymer with a strong acid to form a propionic acid of the polymer. |
申请公布号 |
EP1756173(A2) |
申请公布日期 |
2007.02.28 |
申请号 |
EP20050711695 |
申请日期 |
2005.01.21 |
申请人 |
NEKTAR THERAPEUTICS AL, CORPORATION |
发明人 |
KOZLOWSKI, ANTONI;MCMANUS, SAMUEL, P. |
分类号 |
C07C67/31;C08F8/12;C08F8/14;C08F232/00;C08G65/332 |
主分类号 |
C07C67/31 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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