LAMININ RECEPTOR TARGETING METHOD FOR DELIVERING A TOXIC AGENT INSIDE A CELL

摘要

The present invention is based, at least in part, on the discovery that laminin binding protein p67 (LBP/p67) is internalized, and thus able to deliver toxic agents into cells, e.g. t cancer cells which express LBP/p67, to thereby induce cytotoxicity. In 5 another embodiment, a cell expressing LBP/p67 is exposed to a complex comprising a toxic agent and an LBP/p67 targeting agent, e.g., an LBP/p67 specific ligand or an LBP/p67 specific antibody, or a fragment thereof. In one embodiment, the toxic agent i conjugated to the LBP/p67 targeting agent. The LBP/p67 targeting agent directs the toxin to the cancer cell expressing LBP/p67 and the complex is internalized by the cell, 0 resulting in selective cytotoxicity of the cancer cell.