发明名称 |
Specific inhibitors of NFAT activation by calcineurin and their use in treating immune-related diseases |
摘要 |
Isolated peptide fragments of the conserved regulatory domain of NFAT protein capable of inhibiting protein-protein interaction between calcineurin and NFAT, or a biologically active analog thereof are described. Isolated polynucleotides and gene therapy vectors encoding such peptide fragments are also described. In addition, methods for treating immune-related diseases or conditions and methods for high throughput screening of candidate agents are described. Pharmaceutical compositions are also provided.
|
申请公布号 |
US2007042403(A1) |
申请公布日期 |
2007.02.22 |
申请号 |
US20060474218 |
申请日期 |
2006.06.23 |
申请人 |
HOGAN PATRICK G;RAO ANJANA;ARAMBURU JOSE |
发明人 |
HOGAN PATRICK G.;RAO ANJANA;ARAMBURU JOSE |
分类号 |
C12Q1/68;A61K;A61K38/00;A61K38/17;C07H21/04;C07K5/103;C07K14/71;C12P21/06;G01N33/53 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|