ARTIFICIAL PROTEIN EXPRESSED PANCREATIC beta-CELL-SPECIFICALLY, REPORTER GENE ENCODING THE PROTEIN AND METHOD FOR MEASURING AMOUNT OF PANCREATIC betaCELL

摘要

PROBLEM TO BE SOLVED: To provide a method for simply measuring pancreatic β-cells, comprising making a reporter gene structurally expressed in the pancreatic β-cells and secreted in blood, and transducing the reporter gene into each of various recipient cells as a transgene.

SOLUTION: The artificial reporter gene prepared by fusing a human albumin gene containing a signal sequence with human C-peptide, and a vector incorporated with the artificial reporter gene, and an artificial protein encoding the vector. The amount of the pancreatic β-cells can be estimated by measuring the artificial protein secreted by the recipient cells.

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