CORE-MODIFIED TERPENE TRILACTONES FROM GINKGO BILOBA EXTRACT AND BIOLOGICAL EVALUATION THEREOF
摘要
Lactone-rings of ginkgolides are converted into the corresponding tetrahydrofuran moieties via DIBAL-H reduction followed by deoxygenation of the formed lactols with Et<SUB>3</SUB>SiH/BF<SUB>3</SUB>Et<SUB>2</SUB>O producing a series of lactol-free ginkgolides. The present invention also relates to synthesis of hydroxyl-free, or hydroxyl-free and lactone- free, ginkgolides and bilobalides .
申请公布号
WO2007002410(A3)
申请公布日期
2007.02.15
申请号
WO2006US24492
申请日期
2006.06.22
申请人
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;NAKANISHI, KOJI;DZYUBA, SERGEI;ISHII, HIDEKI
